Compendium
Cognitive

PACAP-38

Pituitary Adenylate Cyclase-Activating Polypeptide-38 is a neuropeptide with broad neurotrophic, anti-apoptotic, and neuroprotective effects. It stimulates cAMP signaling and modulates stress responses.

Protocol

Intranasal research dosing under investigation

Half-Life

~5 minutes (tissue effects prolonged)

Molecular Structure & Chemistry

11 residues • 174 atoms • Skeletal Formula

Formula

C54H87N13O18S2

Molar Mass

1,072.33 g/mol

Exact Mass

1269.574 Da

Isoelectric Pt

2.99

Charge pH 7

-1

GRAVY

+0.23

Hover Cα carbons for residue info

Amino Acid Sequence

GFSMITQLMDQ

Biological Mechanisms

Neuroprotection

Observed in clinical research as a primary mechanism of action for PACAP-38.

Enhanced neuroplasticity

Observed in clinical research as a primary mechanism of action for PACAP-38.

BDNF upregulation

Observed in clinical research as a primary mechanism of action for PACAP-38.

Anti-inflammatory in the brain

Observed in clinical research as a primary mechanism of action for PACAP-38.

Improved memory under stress

Observed in clinical research as a primary mechanism of action for PACAP-38.

Safety & Risk Analysis

HeadacheMigraine-like episodesVasodilationLimited human data

Critical Safety Warning

Black market peptides can be contaminated, mislabeled, or dangerous. Only obtain peptides via a registered doctor and legitimate pharmacy. Never attempt self-administration without professional medical supervision.

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Quick Reference

CategoryCognitive
Half-Life~5 minutes (tissue effects prolonged)
AdminSubcutaneous
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Medical Note

This compound is for research purposes only. Clinical applications must be directed by a licensed physician.

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