Compendium
Cosmetic

Palmitoyl Pentapeptide-4 (Matrixyl)

Matrixyl (Palmitoyl Pentapeptide-4) is a lipopeptide that stimulates collagen and hyaluronic acid synthesis in the skin, signaling aging skin to repair itself and increase extracellular matrix production.

Protocol

3–8% in topical formulations

Half-Life

N/A (topical)

Molecular Structure & Chemistry

20 residues • 302 atoms • Skeletal Formula

Formula

C97H145N25O33S2

Molar Mass

1,893.19 g/mol

Exact Mass

2251.989 Da

Isoelectric Pt

5.91

Charge pH 7

-0.07

GRAVY

-0.44

Hover Cα carbons for residue info

Amino Acid Sequence

GKTYSAQMNATYVSCWQSDI

Biological Mechanisms

Collagen stimulation

Observed in clinical research as a primary mechanism of action for Palmitoyl Pentapeptide-4 (Matrixyl).

Reduced wrinkle depth

Observed in clinical research as a primary mechanism of action for Palmitoyl Pentapeptide-4 (Matrixyl).

Improved skin firmness

Observed in clinical research as a primary mechanism of action for Palmitoyl Pentapeptide-4 (Matrixyl).

Hyaluronic acid production

Observed in clinical research as a primary mechanism of action for Palmitoyl Pentapeptide-4 (Matrixyl).

Skin repair signaling

Observed in clinical research as a primary mechanism of action for Palmitoyl Pentapeptide-4 (Matrixyl).

Safety & Risk Analysis

MinimalPossible mild irritationVery safe topically

Critical Safety Warning

Black market peptides can be contaminated, mislabeled, or dangerous. Only obtain peptides via a registered doctor and legitimate pharmacy. Never attempt self-administration without professional medical supervision.

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Quick Reference

CategoryCosmetic
Half-LifeN/A (topical)
AdminSubcutaneous
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Medical Note

This compound is for research purposes only. Clinical applications must be directed by a licensed physician.

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