Compendium

Cosmetic Peptides

Peptides used in skincare and aesthetics for wrinkle reduction, collagen stimulation, and skin repair.

Cosmetic

Argireline (Acetyl Hexapeptide-3)

Argireline is a synthetic hexapeptide that mimics the N-terminal portion of SNAP-25, competitively inhibiting the SNARE complex to reduce muscle micro-contraction and expression line depth.

Wrinkle reductionTopical Botox-like effect
Cosmetic

EGF (Epidermal Growth Factor)

Epidermal Growth Factor is a 53-amino-acid protein that stimulates cell proliferation, differentiation, and wound healing via the EGF receptor. In skincare, recombinant EGF promotes skin regeneration.

Skin cell proliferationCollagen stimulation
Cosmetic

Leuphasyl

Leuphasyl is a pentapeptide that modulates enkephalin receptors in muscle cells, reducing acetylcholine release and decreasing muscle contraction. Often combined with Argireline for synergistic wrinkle reduction.

Expression wrinkle reductionEnkephalin receptor modulation
Cosmetic

Palmitoyl Pentapeptide-4 (Matrixyl)

Matrixyl (Palmitoyl Pentapeptide-4) is a lipopeptide that stimulates collagen and hyaluronic acid synthesis in the skin, signaling aging skin to repair itself and increase extracellular matrix production.

Collagen stimulationReduced wrinkle depth
Cosmetic

Palmitoyl Tetrapeptide-7

Palmitoyl Tetrapeptide-7 (Rigin) is a lipopeptide fragment of IgG that suppresses excess IL-6, a key driver of skin inflammation and aging. Used with Matrixyl as Matrixyl 3000 to reduce puffiness.

Reduces skin inflammationIL-6 suppression
Cosmetic

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-1 (Matrixyl 3000 component) is a lipopeptide fragment of collagen that stimulates collagen type I, III synthesis and glycosaminoglycan production, improving skin density and firmness.

Collagen type I and III synthesisGlycosaminoglycan production
Cosmetic

SNAP-8

SNAP-8 is an octapeptide and extended version of Argireline. By elongating the chain, it more effectively blocks the SNARE complex, resulting in greater reduction of expression lines.

Greater wrinkle reduction than ArgirelineExpression line smoothing
Cosmetic

SYN-AKE

SYN-AKE is a synthetic tripeptide mimicking Waglerin-1 from Temple Viper venom. It blocks nicotinic acetylcholine receptors at neuromuscular junctions to smooth expression lines without injection.

Neurotoxin-mimicking wrinkle reductionExpression line smoothing